Desperately Seeking Susan— Full Cast

Rosanna Arquette

as Roberta Glass

Madonna

as Susan

Aidan Quinn

as Dez

Mark Blum

as Gary Glass

Robert Joy

as Jim

Laurie Metcalf

as Leslie Glass

Anna Thomson

as Crystal

Will Patton

as Wayne Nolan

Steven Wright

as Larry Stillman D.D.S.

John Turturro

as Ray

Giancarlo Esposito

as Street Vendor

Richard Hell

as Bruce Meeker

Rockets Redglare

as Taxi Driver

Annie Golden

as Band Singer

Richard Edson

as Man With Newspapers