The Sisters Brothers— Full Cast

John C. Reilly

as Eli Sisters

Joaquin Phoenix

as Charlie Sisters

Jake Gyllenhaal

as John Morris

Riz Ahmed

as Hermann Kermit Warm

Rebecca Root

as Mayfield

Allison Tolman

as Girl Mayfield Saloon

Rutger Hauer

as The Commodore

Carol Kane

as Mrs Sisters

Patrice Cossonneau

as Blount

Zac Abbott

as Blount Guy Dying

David Gasman

as Relay Owner

Philip Rosch

as Storekeeper Pioneer Town 2

Creed Bratton

as Quarrel Saloon Guy Town 02

Lenuta Bala

as Woman with the Bortsch

Jochen Hägele

as Horse Dealer Town 03